Substituted semi-carbazones and related compounds

ABSTRACT

Substituted semicarbazones, thiosemicarbazones and isothiosemicarbazones and salts thereof, intermediates therefor, synthesis thereof, and the use of said compounds for the control of weeds.

This is a division of Ser. No. 74,197 filed July 16, 1987, now abandoned, which is a continuation-in-part of Ser. No. 009,963, filed Feb. 2, 1987, now abandoned, which is a continuation-in-part of Ser. No. 894,990, which are incorporated herein by reference.

This invention relates to novel substituted semicarbazones, thiosemicarbazones and isothiosemicarbazones and salts thereof, intermediates therefor, synthesis thereof, and the use of said compounds for the control of weeds.

More particularly, the compounds of the present invention are represented by the following formula (A): ##STR1## wherein, R is the group ##STR2## each of R³ and R⁴ is independently hydrogen or lower alkyl; R⁵ is hydrogen, lower alkyl, lower haloalkyl, lower alkoxyalkyl, unsubstituted or substituted phenyl, alkali cation, earth cation, ammonium cation, substituted ammonium cation, phosphonium cation, trialkylsulfonium cation, trialkylsulfoxonium cation or the group ##STR3## each of R⁶ and R⁹ is lower alkyl, lower alkenyl, phenyl or benzyl;

each of R⁷ and R⁸ is independently hydrogen or lower alkyl; or R⁷ and R⁸ are taken together to form a lower alkylene bridge of three to six carbon atoms, optionally including one of O, S or NH in the ring;

R¹⁰ is the group ##STR4## each of R¹¹ and R¹² is independently hydrogen or lower alkyl or lower alkoxyalkyl;

R¹³ is hydrogen or lower alkyl;

m is zero or one;

Q is oxygen, sulfur or N--R¹³ ;

each of W, W', W" and W'" is nitrogen or CH; each of X and X' is independently oxygen or sulfur; and each of Y, Z, Z¹, Z² and Z³ is independently hydrogen, lower alkyl, lower haloalkyl, lower alkoxy, lower haloalkoxy, lower alkenyloxy, lower haloalkenyloxy, lower alkynyloxy, lower alkylthio, phenyl, phenoxy, hydroxy, halogen, nitro, cyano, amino, lower alkylamino or dialkylamino;

with the proviso that when R is phenyl, then R³ cannot be hydrogen.

In the description and claims hereinafter, each of m, Q, R--R¹², W--W'", X, X', Y, and Z--Z³ is as defined above, unless otherwise noted.

The compounds of the present invention of formula (A) ##STR5##

In the above synthesis, the carbonyl compound (I) and the semicarbazide or thiosemicarbazide (II) are reacted together at room temperature in the presence of an alcohol solvent such as methanol or ethanol and with or without an acid catalyst to give the semicarbazones (A').

Some of the semicarbazides and thiosemicarbazides of formula (II) are known compounds, such as those where R¹⁰ is optionally substituted phenyl. Others of formula (II), such as where R¹⁰ is optionally substituted pyridyl, are new compounds. Generally, the semicarbazides and thiosemicarbazides can be synthesized by the reaction of hydrazine hydrate with either:

a) an isocyanate or isothiocyanate of formula (IV) in an organic solvent at a temperature below room temperature, or

b) a carbamate or thiocarbamate of formula (V) (where R²⁰ is lower alkyl or phenyl) in an organic solvent and at reflux temperature, or

c) a urea of formula (VI) in an organic solvent and at reflux temperature. ##STR6##

The following terms, wherever used in the description herein and in the appended claims, have the meaning defined below, unless otherwise specified hereinafter.

The term "lower alkyl" refers to an alkyl group, straight or branched, having a chain length of one to eight carbon atoms.

The term "lower alkoxy" refers to an alkoxy group, straight or branched, having a chain length of one to eight carbon atoms.

The term "lower haloalkyl" refers to a lower alkyl group substituted with one to six halogen atoms.

The term "lower haloalkoxy" refers to a lower alkoxy group substituted with one to six halogen atoms.

The term "lower alkylthio" refers to a lower alkylthio group, straight or branched, having a chain length of one to eight carbon atoms.

The term "lower alkoxyalkyl" refers to a lower alkyl group substituted with a lower alkoxy group, the total number of carbon atoms being two to ten.

The term "lower alkylamino" refers to a lower alkyl group substituted with an amino group.

The term "lower alkenyl" refers to an alkenyl group straight or branched, having one or two ethylenic bonds and having a chain length of two to eight carbon atoms.

The term "substituted phenyl" refers to a phenyl ring substituted at one to three of the ring carbon atoms with a group selected from lower alkyl, lower haloalkyl, lower alkoxy, lower haloalkoxy or halogen.

The term "substituted ammonium cation" refers to an ammonium cation substituted by a C₁₋₂₀ alkyl, di-C₁₋₂₀ alkyl, tri-C₁₋₂₀ alkyl, tetra-C₁₋₂₀ alkyl, hydroxy-C₁₋₅ alkyl, di(hydroxy-C₁₋₅ alkyl), tri(hydroxy-C₁₋₅ alkyl), C₁₋₅ alkoxy-C₁₋₅ alkyl, hydroxy-C₁₋₅ alkoxy-C₁₋₅ alkyl or C₁₋₅ alkoxycarbonyl-C₁₋₅ alkyl group.

The compounds of the present invention may exist in either the syn or the anti form, although the anti form usually predominates. The present invention includes both isomeric forms.

The novel compounds of formula (A) are useful for the control of weeds, using pre- and/or post-emergent treatments They are also useful as plant growth regulators. The compounds can be applied in the form of dusts, granules, solutions, emulsions, wettable powders, flowables and suspensions. Application of a compound of the present invention is made according to conventional procedure to the weeds or their locus using an herbicidally effective amount of the compounds, usually from about one-half or less to ten pounds per acre. The application of a compound of the present invention to the "locus" of the weed includes application to the seeds, the plant (weed) or parts of the plant, or the soil.

Methods of preparing herbicidal formulations which can be used with a compound of the present invention are described in the literature along with suitable liquid and solid carriers, such as in U.S. Pat. Nos. 4,192,669 and 4,163,661, which are incorporated herein by reference The optimum usage of a compound of the present invention is readily determinable by one of ordinary skill in the art using routine testing such as greenhouse testing and small plot testing.

The term "herbicide," as used herein, refers to an active ingredient which modifies the growth of plants because of phytotoxic or plant growth regulating properties so as to retard the growth of the plant or damage the plant sufficiently to kill it.

While some of the compounds of the present invention have activity on grass weeds, the compounds, in general, demonstrate a higher level of herbicidal activity on broadleaf plants when applied postemergence. Broadleaf plant (weed) species on which the compounds of the present invention show effective herbicidal activity include, but are not limited to, mustard, pigweed, velvetleaf, jimsonweed, cocklebur, sicklepod and annual morning glory.

The compounds of the present invention, when applied pre-emergence, demonstrate high levels of herbicidal activity on both broadleaf and grass weeds.

The compounds of formula A in which R is an optionally substituted is isothiazole or optionally substituted pyridine are suitable for the selective control of weeds in certain crop plants. These compounds, and especially the isothiazoles, are particularly suitable for use in a corn locus. The isothiazoles also show selectivity in a soybean locus.

Compounds of this invention may be advantageously combined with other herbicides for broadspectrum weed control. Examples of herbicides which can be combined with a compound of the present invention include those selected from the carbamates, thiocarbamates, chloroacetamides, trizines, dinitroanilines, benzoic acids, glycerol ethers, pyridazinones, uracils and ureas for controlling a broad spectrum of weeds.

The following examples are provided to illustrate the practice of the present invention. Temperature is given in degrees Centigrade "RT" means room temperature. Parts and percentages are by weight. The symbols *, # and + when used in connection with melting points mean "gas", "softens" and "decomposes", respectively.

FINAL PRODUCTS

To a solution of 2-acetylnicotinic acid (0.40 g, 2.4 mmol) in 7 ml of methanol is added a solution of 4-phenylsemicarbazide (0.37 g, 2.4 mmol) in 5 ml of methanol. The mixture is stirred at RT overnight, after which the solid precipitate is collected by filtration, washed with ethanol and dried to give 2-acetylnicotinic acid 4-phenylsemicarbazone, m.p. 174° (dec.) (compound 1, Table A).

EXAMPLE 2

2-Acetylbenzoic acid (0.50 g, 3.0 mmol) and 2-methyl-4-(3-trifluoromethyl)phenylsemicarbazide (0.67 g, 3.0 mmol) are dissolved together in 15 ml of ethanol. After 3 hours at RT, 50 mg of pyridyl tosylate is added. After 2 more hours, the precipitated solid is collected by filtration and dried to give 2-acetylbenzoic acid 2-methyl-4-(3-trifluoromethylphenyl)semicarbazone, m.p. 172° (gas) (compound 2, Table A).

EXAMPLE 3

Following the procedure of either Example 1 or Example 2, each of the semicarbazone or thiosemicarbazone compounds 3-47, 155-161, 217, 218 and 240-243 under Table A; 48-52, 203-205 and 210 under Table B; 63-79 under Table C; 87-100 under Table D; and 105-144, 174-189, 213-216 and 221-237 under Table E is prepared from the corresponding semicarbazide or thiosemicarbazide and acetyl compound.

EXAMPLE 4

To a solution of 2-acetylnicotinic acid 4-phenylsemicarbazone (0.32 g) in 5 ml of methanol is added 1 equivalent of sodium methoxide. The mixture is stirred at RT for 5 min., after which the solvent is removed by rotoevaporation to give the sodium salt of 2-acetylnicotinic acid 4-phenylsemicarbazone, m.p. 203° (dec.).

Following the above procedures, each of the acids under Tables A, B, C, D, E and F is treated with 1 equivalent of sodium methoxide to give the corresponding sodium salt.

EXAMPLE 5

To 2-acetylnicotinic acid 4-phenylsemicarbazone (0.32 g) in 5 ml of methanol is added 1 equivalent of an aqueous solution of ammonium hydroxide. The mixture is stirred at RT for 5 min , after which the solvent is removed by rotoevaporation to give the ammonium salt of 2-acetylnicotinic acid 4-phenylsemicarbazone, m.p. 146°-150° (softens) and 198°-200° (gas).

Following the above procedures, each of the acids under Tables A, B, C, D, E and F is treated with 1 equivalent of aqueous ammonium hydroxide to give the corresponding ammonium salt.

EXAMPLE 6

Following the procedures of Example 5, using isopropylamine, 2-hydroxyethylamine, di-2-hydroxyethylamine, tri-2-hydroxyethylamine, diisopropylamine, 2-(2-hydroxyethoxy)ethylamine, dimethylamine, octylamine, tetradecylamine or piperidine, the following salts are obtained:

Of compound 1, the isopropylammonium salt, m p 94° (softens), 120° (gas)

Of compound 4, the isopropylammonium salt, m.p. 111°-118°

Of compound 31, the isopropylammonium salt, m.p. 111°-113°

Of compound 104, the isopropylammonium salt, m.p.>300°

Of compound 141, the isopropylammonium salt, m.p. 113°-122°

Of compound 152, the isopropylammonium salt, m.p. 98°-110°

Of compound 154, the isopropylammonium salt, m.p. 151° (gas)

Of compound 195, the isopropylammonium salt, m.p. 61°-63°

Of compound 196, the isopropylammonium salt, m.p. 70°-73°

Of compound 197, the isopropylammonium salt, m.p. 57°-60°

Of compound 198, the isopropylammonium salt, m.p. 66°-68°

Of compound 204, the isopropylammonium salt, m.p. 265°-269° (dec)

Of compound 1, the 2-hydroxyethylammonium salt, m.p. 131° (gas)

Of compound 3, the 2-hydroxyethylammonium salt, m.p. 159°-164° (dec)

Of compound 4, the 2-hydroxyethylammonium salt, m.p. 164°-166°

Of compound 22, the 2-hydroxyethylammonium salt, m.p. 118° (gas)

Of compound 30, the 2-hydroxyethylammonium salt, m.p. 158° (softens), 201°-104°

Of compound 141, the 2 hydryoxethylammonium salt, m.p. 78°-86°

Of compound 184, the 2-hydroxyethylammonium salt, m.p. 165° (gas)

Of compound 185, the 2-hydroxyethylammonium salt, m.p. 75° (softens), 95°

Of compound 186, the 2-hydroxyethylammonium salt, m.p. 82°-84°

Of compound 3, the di-2-hydroxyethylammonium salt, m.p. 134°-185°

Of compound 4, the di-2-hydroxyethylammonium salt, m.p. 184°-186°

Of compound 30, the di-2-hydroxyethylammonium salt, m.p. 127° (gas)

Of compound 141, the di-2-hydroxyethylammonium salt, m.p. 174°

Of compound 142, the di-2-hydroxyethylammonium salt, m.p. 168°

Of compound 152, the di-2-hydroxyethylammonium salt, m.p. 108° (softens), 112° (dec)

Of compound 179, the di-2-hydroxyethylammonium salt, m.p. 162°-168°

Of compound 184, the di-2-hydroxyethylammonium salt, m.p. 168° (gas)

Of compound 185, the di-2-hydroxyethylammonium salt, m.p. 148°-151°

Of compound 186, the di-2-hydroxyethylammonium salt, m.p. 168°-170°

Of compound 188, the di-2-hydroxyethylammonium salt, m.p. 48°-70° (sinters), 157°-161°

Of compound 195, the di-2-hydroxyethylammonium salt, m.p. 128°-130°

Of compound 197, the di-2-hydroxyethylammonium salt, m.p. 177°-179° (dec)

Of compound 207, the di-2-hydroxyethylammonium salt, m.p. 137°-140°

Of compound 3, the tri-2-hydroxyethylammonium salt, m.p. 154°-158°

Of compound 4, the tri-2-hydroxyethylammonium salt, m.p. 65°-68°

Of compound 30, the tri-2-hydroxyethylammonium salt, m.p. 138°-140°

Of compound 141, the tri-2-hydroxyethylammonium salt, m.p. 140° (gas)

Of compound 3, the diisopropylammonium salt, m.p. 208°-210°

Of compound 4, the diisopropylammonium salt, m.p. 210°-220°

Of compound 3, the 2-(2-hydroxyethoxy)ethylammonium salt, m.p. 159°-167° (dec)

Of compound 30, the 2-(2-hydroxyethoxy)ethylammonium salt, m.p. 140°-142°

Of compound 31, the 2-(2-hydroxyethoxy)ethylammonium salt, m.p. 79°-82°

Of compound 141, the 2-(2-hydroxyethoxy)ethylammonium salt, m.p. 150°

Of compound 3, the dimethylammonium salt, m.p. 155°-180°

Of compound 4, the dimethylammonium salt, m.p. 98°-101°

Of compound 141, the dimethylammonium salt, m.p.. 163°-165°

Of compound 142, the dimethylammonium salt, m.p. 230°

Of compound 152, the dimethylammonium salt, m.p. 138°-140° (gas)

Of compound 195, the dimethylammonium salt, m.p. 53°-55°

Of compound 206, the dimethylammonium salt, m.p. 145°-153°

Of compound 3, the octylammonium salt, m.p. 142°-148°

Of compound 4, the octylammonium salt, m.p. 204°-207°

Of compound 30, the octylammonium salt, m.p. 156° (softens), 210°

Of compound 141, the octylammonium salt, m.p. 245°-255°

Of compound 3, the tetradecylammonium salt, m.p. 125°-129°

Of compound 4, the tetradecylammonium salt, m.p. 214°-216°

Of compound 30, the piperidino salt, m.p. 136°.

(For the structure of compounds 1, 3, 4, 22, 30, 31 and 154, see Table A. For the structure of compound 204, see Table B. For the structure of compounds 141, 142, 167, 179, 184, 185, 186 and 188, see Table E. For the structure of compounds 151, 152 and 195-198, see Table F. For the structure of compound 104, see Example 11 For the structure of compounds 206 and 207, see Example 18.)

EXAMPLE 7

A solution of ethyl 2-methylnicotinate (2.0 g, 12.12 mmol), selenium dioxide (20.0 g, 18.18 mmol) and dioxane (10 ml) is heated at 135° for 4 hours. The reaction mixture is filtered and the filtrate is concentrated and purified by prep. TLC to give ethyl 2-formylnicotinate.

Ethyl 2-formylnicotinate (1.0 g, 5.58 mmol) in 1 ml of ethanol is added to an aqueous solution of lithium hydroxide (0 28 g, 6.70 mmol) in 3 ml of water. The mixture is stirred at RT for 2 hours, then concentrated under vacuum at RT. The resulting lithium salt of 2-formylnicotinic acid is dissolved in 5 ml of methanol, and 4-phenylsemicarbazide (0.77 g, 5.07 mmol) is added. The mixture is stirred at RT overnight The resulting white precipitate is filtered and washed with methanol to give the lithium salt of 2-formylnicotinic acid 4-phenylsemicarbazone, m.p. 266°.

Following the above procedure, the lithium salt of 2-acetylnicotinic acid 4-(3-fluorophenyl)semicarbazone, m.p. 208°-209°, is prepared.

EXAMPLE 8

To a solution of the sodium salt of compound 4 (1.50 g, 4.4 mmol) in 18 ml of methanol is added, with stirring, calcium chloride (0 25 g, 2.2 mmol) in 5 ml of methanol. After ca. 2 hours, the resulting gel-like material is filtered, and the filter pad is washed with water and air-dried to give a white solid which, upon further drying under vacuum at 50° for 3 hours and then at RT overnight, yields the calcium salt of compound 4, m.p. 194°-195°.

EXAMPLE 9

A suspension of 2-acetylnicotinic acid 4-phenylsemicarbazone (compound 1) (0.50 g) in 20 ml of methanol is treated with diazomethane until the yellow color of the solution persists. The solvent is removed in vacuo to give methyl 2-acetylnicotinate 4-phenylsemicarbazone, m.p. 177°-178° (compound 53, Table C).

EXAMPLE 10

A mixture of the sodium salt of compound 4 (1.0 g, 3.0 mmol) and chloromethyl acetate (0.4 g, 3.5 mmol) in 18 ml of DMF is stirred at RT for 3 days. The reaction mixture is poured onto ice. The solid which precipitates is collected by filtration, is washed with water and is air-dried. It is stirred in 50 ml of chloroform for 2 hours and is filtered. The filtrate is evaporated to give glass-like material, which is triturated with ether to give the crude product. Purification by prep. TLC gives acetyloxymethyl 2-acetylnicotinate 4-(3-fluorophenyl)semicarbazone, m.p. 159°-160° (compound 54, Table C).

Following the above procedure, each of the semicarbazone compounds 55-62, 80-86 and 162-173 in Table C; compounds 190-194, 211, 212, 219, 220, 238 and 239 in Table E; and compounds 200-202 in Table F is prepared from the corresponding sodium salt of the semicarbazone carboxylate.

EXAMPLE 11

A mixture of methyl 3-oxo-2-(2-nitrobenzylidenyl)pentanoate (2.0 g, 7.8 mmol) and iron (2.2 g, 40.0 mmol) in 25 ml of acetic acid is heated at 80° until gas evolution begins. The mixture is allowed to cool to RT and the iron is removed. The mixture is filtered and the filtrate is stripped. The residue is taken up in chloroform, stirred with decolorizing carbon and sodium sulfate and filtered. The solvent is removed by vacuum and the residue is purified by column chromatography to give methyl 2-ethyl-3-quinolinecarboxylate.

A mixture of the above carboxylate (0.22 g, 1.0 mmol) and bromine (0.22 g, 1.4 mmol) in 5 ml of carbon tetrachloride is heated to reflux under floodlamp irradiation and with ca. 5 mg of benzoyl peroxide. After ca. 4 hours, the reaction mixture is cooled to RT and decanted, and the residue is washed with chloroform. The organic layers are combined and the solvent is removed under vacuum to give methyl 2-(1-bromoethyl)-3-quinolinecarboxylate.

A mixture of the above bromide (1.0 mmol) and sodium bicarbonate (0.65 g, 7.7 mmol) in 5 ml of dimethylsulfoxide (DMSO) is quickly heated to 110° and heating is continued for 45 min. The reaction mixture is cooled to RT, diluted with chloroform, washed with water and dried and the solvent is removed in vacuo. The crude product is purified by prep. TLC to give methyl 2-acetyl-3-quinolinecarboxylate.

Following the procedure of Example 30, methyl 2-acetyl-3-quinolinecarboxylate is reacted with lithium hydroxide monohydrate and with hydrochloric acid to give the corresponding acid.

Following the procedure of Example 2, each of 2-acetyl-3-quinolinecarboxylic acid, 3-acetyl-2-quinolinecarboxylic acid and 3-acetyl-4-quinolinecarboxylic acid is reacted with 4-phenylsemicarbazide to give, respectively,

2-acetyl-3-quinolinecarboxylic acid 4-phenylsemicarbazone, m.p. 234°-236° (compound 101);

3-acetyl-2-quinolinecarboxylic acid 4-phenylsemicarbazone, m.p. 243° (gas) (compound 102); and

3-acetyl-4-quinolinecarboxylic acid 4-phenylsemicarbazone, m.p. 251° (dec.) (compound 103).

In the same manner, 3-acetyl-4-quinolinecarboxylic acid is reacted with 4-(3-chlorophenyl)semicarbazide to give 3-acetyl-4-quinolinecarboxylic acid 4-(3-chlorophenyl)semicarbazone, m.p. 229° (compound 104).

EXAMPLE 12

Following the procedure of Example 4, each of compounds 101-104 is reacted with sodium methoxide to give:

the sodium salt of compound 101, m.p. 224°-225° (gas);

the sodium salt of compound 102, m.p.>300°;

the sodium salt of compound 103, m.p.>300°; and

the sodium salt of compound 93, m.p.>300°.

To a suspension of 2-acetyl-3-nicotinic acid N-oxide (2.5 g, 13.8 mmol) in 40 ml of ethanol is added 4-phenylsemicarbazide (2.1 g, 13.8 mmol). The mixture is stirred at 40° overnight, after which the solvent is removed and the product purified to give 2-acetyl-3-nicotinic acid N-oxide 4-phenylsemicarbazone, m.p. 218° (dec.) (compound 145).

In the same manner, 2-acetyl-3-nicotinic acid N-oxide (1.5 g, 8.3 mmol) and 2-methyl-4-phenylsemicarbazide are reacted together to give 2-acetyl-3-nicotinic acid N-oxide 2-methyl-4-phenylsemicarbazone, m.p. 55° (softens), 65° (melts) (compound 146).

Following the procedure of Example 4, the sodium salt of 2-acetyl-3-nicotinic acid N-oxide 4-phenylsemicarbazone is prepared, m.p. 128°-133°.

Following the procedure of Example 5, the ammonium salt of 2-acetyl-3-nicotinic acid N-oxide 4-phenylsemicarbazone is prepared, m.p. 137° (softens), 155° (gas).

EXAMPLE 14

A mixture of 2-acetylnicotinic acid (1.2 g, 7.3 mmol), oxalyl chloride (1.0 g, 8.0 mmol), DMF (1 drop) in 10 ml of benzene is stirred at RT for 3 hours. The reaction mixture is then decanted and the solvent is removed in vacuo to give the corresponding acid chloride. The acid chloride is taken up in 30 ml of chloroform, and diethylamine (2-3 ml) is added. The mixture is stirred at RT for 1 hour, after which it is stripped. The residue is dissolved in 50 ml of chloroform and washed with water and with sat. sodium chloride. The organic layer is separated and dried and the solvent is removed by rotoevaporation to give N,N-diethyl 2-acetyl-3-nicotinamide.

A mixture of the above nicotinamide (0.45 g, 2 0 mmol) and 4-phenylsemicarbazide (0.31 g, 2.0 mmol) in 10 ml of acetic acid is stirred at RT overnight. The solvent is then removed by rotoevaporation, and the residue is triturated with methanol. The solid is collected by filtration and is dried to give N,N-diethyl 2-acetyl-3-nicotinamide 4-phenylsemicarbazone, m.p. 241°-243° (compound 147).

Following the above procedures, each of 4-(3-fluorophenyl)semicarbazide and 4-(3-chlorophenyl)semicarbazide is reacted with N,N-diethyl 2-acetyl-3-nicotinamide to give N,N-diethyl 2-acetyl-3-nicotinamide 4-(3-fluorophenyl)semicarbazone (compound 148) and N,N-diethyl 2-acetyl-3-nicotinamide 4-(3-chlorophenyl)semicarbazone (compound 149), respectively.

Following the procedures of Example 14, 2-acetylnicotinic acid chloride (1.0 g, 5.5 mmol) and morpholine (0.6 g, 6.7 mmol) are reacted together to give 4-(2-acetylnicotinyl)morpholine, which compound (1.0 g, 4.2 mmol) is then reacted with 4-(3-fluorophenyl)semicarbazide (0.7 g, 4.2 mmol) to give 4-(2-acetylnicotinyl)morpholine 4-(3-fluorophenyl)semicarbazone, m.p. 193°-195° compound 150).

EXAMPLE 16

To a mixture of compound 13 (8.0 g, 23.4 mmol) and potassium carbonate (6.5 g, 47.0 mmol) in 50 ml of dimethylformamide is added 2.9 ml (6.67 g, 47.0 mmol) of methyl iodide. The mixture is stirred at RT overnight, and is then poured into ether/CHCl₃ and water. The organic phase is separated, washed with sodium bicarbonate and with brine and dried and the solvent is removed to give, following crystallization from CH₃ CN, the corresponding isothiosemicarbazone (compound 151(A), Table F) as a mixture of isomers.

To a suspension of the above ester (5.2 g, 15.2 mmol) in 80 ml of methanol is added a solution of lithium hydroxide monohydrate (0.638 g, 15.2 mmol) in 7 ml of water. The suspension is heated to 60° for 7 days, after which the reaction mixture is cooled and the solid is filtered out. The remaining solution is concentrated by rotoevaporation, and conc. HCl and water are added. The resulting solid is collected by vacuum filtration to give compound 151 under Table F.

EXAMPLE 17

To a suspension of compound 14 (15.0 g, 43.1 mmol) in 110 ml of methanol is added sodium methoxide (4.65 g, 86.2 mmol), followed by addition of methyl iodide (6.12 g, 43.1 mmol). The mixture is stirred at RT for 3 hours, after which the solvent is removed by rotoevaporation. The residue is taken up in water and extracted with chloroform. The aqueous fraction is acidified with dilute HCl and extracted with chloroform. This chloroform extract is washed with water and with brine and dried, and the solvent is removed to give compound 152 under Table F.

Following the above procedures, compound 159 is reacted with each of methyl iodide, bromoethane, allyl bromide and benzyl bromide to give, respectively, compounds 195-198 under Table F.

EXAMPLE 18

Following the procedures of Example 17, each of compounds 182 and 183 is reacted with methyl iodide to give, respectively,

3-acetyl-4-isothiazolecarboxylic acid S-methyl-4-(3-chlorophenyl)isothiosemicarbazone, m.p. 149°-153° (compound 206), and

3-acetyl-4-isothiazolecarboxylic acid S-methyl-4-(3-fluorophenyl)isothiosemicarbazone, m.p. 145°-148° (compound 207).

EXAMPLE 19

Following the procedure of Example 4, each of compounds 206 and 207 is reacted with sodium methoxide to give:

the sodium salt of compound 206, m.p. 122°-130°, and

the sodium salt of compound 207, m.p. 116°-136°.

EXAMPLE 20

Following the procedure of Example 10, the sodium salt of each of compounds 206 and 207 is reacted with chloromethyl 2,2-dimethylpropanoate to give, respectively,

t-butylcarbonyloxymethyl 3-acetyl-4-isothiazolecarboxylate S-methyl-4-(3-chlorophenyl)isothiosemicarbazone, viscous yellow oil (compound 208), and

t-butylcarbonyloxymethyl 3-acetyl-4-isothiazolecarboxylate S-methyl-4-(3-fluorophenyl)isothiosemicarbazone, m.p. 68°-74° (compound 209).

                                      TABLE A                                      __________________________________________________________________________      ##STR7##                                      (Formula A.sub.3)               Cpd.                                 m.p.°                              No. W  R.sup.4                                                                               X Z   Z.sup.1 Z.sup.2                                                                             Z.sup.3                                                                            acid Na salt                                                                              NH.sub.4                       __________________________________________________________________________                                                     salt                           1   N  H      O H   H       H    H   174* 203   146#                                                                           200*                           2   CH CH.sub.3                                                                              O H   CF.sub.3                                                                               H    H   172* 148*                                 3   N  H      O H   Cl      H    H   153* 205*                                 4   N  H      O H   F       H    H   159* 220#  140#                                                                     232*  200*                           5   N  H      O H   CF.sub.3                                                                               H    H   163-164                                                                             194*                                 6   N  H      O H   H       Cl   H   227* 213*                                 7   N  H      O Cl  H       H    H   300  131-132*                             8   N  H      O H   Cl      Cl   H   163* 189#                                                                           201*                                 9   N  H      O H   CH.sub.3                                                                               H    H   166-167*                                                                            211*  192#                                                                           207*                           10  N  H      O H   H       F    H   146-149*                                                                            170#                                                                      208-220                                                                             205*                                 11  N  H      O H   OCH.sub.3                                                                              H    H   162-165*                                                                            197*                                 12  N  H      O F   H       H    H   162-165*                                                                            197*                                 13  N  H      S H   H       H    H   158-160                                   14  N  H      S H   Cl      H    H   108-110*                                                                            108+                                 15  N  H      S F   H       H    H   159-161*                                                                            128-130*                             16  N  H      S H   H       F    H   173-174                                                                             159-163                              17  N  H      S H   Cl      Cl   H   169-170                                                                             121-124*                             18  N  H      O H   H       OC.sub.6 H.sub.5                                                                    H   148+ 211*                                 19  N  CH.sub.3                                                                              O H   H       H    H   98-100#                                                                             147-56*+                                                                             140-47                                                              140*                                      20  N  CH.sub.3                                                                              O H   Cl      H    H   69#  118*                                                                      140                                       21  N  CH.sub.3                                                                              O H   F       H    H   120-130                                                                             120#                                                                           140*                                 22  CH H      O H   H       H    H   174  184-86*                                                                              150#                           23  CH H      O H   CF.sub.3                                                                               H    H   164* 255                                  24  CH H      O H   Cl      H    H   158* 126*  87#                                                                            140-147                        25  CH H      O H   F       H    H   169* 203*                                 26  CH H      O H   CF.sub.3                                                                               Cl   H   170* 173*                                 27  CH H      S H   H       H    H   129-131                                                                             115#                                                                           134*                                 28  CH CH.sub.3                                                                              O H   H       H    H   177                                       29  CH CH.sub.3                                                                              O H   H       CH.sub.3                                                                            H   176-178*                                  30  N  H      O H   Cl      H    Cl  193+ 222*                                 31  N  H      O H   F       H    F   186* 240*                                 32  N  H      O F   F       H    H   168# 220*                                                                      202                                       33  N  H      O Cl  Cl      H    H   168# 194*                                                                      198                                       34  N  H      O F   H       H    F   154-157                                                                             234-235*                             35  N  H      O F   H       H    CH.sub.3                                                                           173# 226-227*                                                                  203                                       36  N  H      O H   OCH.sub.3                                                                              H    OCH.sub.3                                                                          185* 203                                  37  N  H      O F   H       H    Cl  167-171*                                                                            204-206+                             38  N  H      O F   Cl      H    H   152-154*                                                                            200-202+                             39  N  H      O H   Cl      Cl   H   163* 189#                                 40  N  H      O H   NO.sub.2                                                                               H    H   190+ 194-195+                             41  N  H      S H   CN      H    H   168-169                                                                             166#                                 42  N  H      O H   Br      H    H   175* 208-210*                             43  N  H      O H   I       H    H   174* 212*                                 44  N  H      O H   OH      H    H   204-210                                   45  N  H      O H   OC.sub.6 H.sub.5                                                                       H    H   164* 206*                                 46  N  H      O H   C.sub.2 H.sub.5                                                                        H    H   178-180*                                                                            200#                                 47  N  H      O H   O -nC.sub.4 H.sub.9                                                                    H    H   172-175*                                                                            207*                                 154 CH H      O H   Cl      H    Cl  185-186                                                                             199-200                              155 N  H      O H   CH.sub.3                                                                               H    CH.sub.3                                                                           198# 228*                                                                      228                                       156 N  H      O H   C(CH.sub.3)CH.sub.2                                                                    H    H   171-173                                                                             213+                                 157 N  H      O H   Br      H    Br  202*                                      158 N  H      S H   CH.sub.3                                                                               H    H   177  198-201*                             159 N  H      S H   F       H    H   168-169*                                                                            170-173                              160 N  H      O H   SCH.sub.3                                                                              H    H   174-175*                                                                            208-209                              161 N  H      O H   OCF.sub.3                                                                              H    H   191-192*                                                                            225-227*                             217 N  H      O H   OCHF.sub.2                                                                             H    H   193* 208-212                              218 N  H      O H   OCF.sub.2 CHF.sub.2                                                                    H    H                                             240 N  CH.sub.2 CH.sub.2 OH                                                                  O H   F       H    H   146-148*                                                                            80-83*                               241 N  H      O H   H       CH.sub.3                                                                            H   218  208*                                 242 N  H      O OCH.sub.3                                                                          H       H    H   148-150                                                                             198-202                              243 N  H      O H   CH.sub.3                                                                               F    H   222-230                                                                             220*                                 __________________________________________________________________________

                  TABLE B                                                          ______________________________________                                          ##STR8##                 (Formula A.sub.4)                                                      m.p.                                                         Cpd.  W        R.sub.10     Acid     Na-salt                                   ______________________________________                                         48    N        2-pyridyl    195-197  183                                       49    N        6-chloro-2-pyridyl                                                                          171-172  190-194                                   50    N        3-pyridyl    167#     208*                                                                  206-208                                            51    CH       2-pyridyl    128-129* 200*                                      52    CH       3-pyridyl    152-153  175+                                      203   N        3-chloro-4-pyridyl                                                                          187-188  201-203+                                  204   N        5-methyl-2-  256-258  242-244                                                  (1,3,4-thiadiazole)                                             205   N        2-thiazole   164#, 235+                                                                              219*                                      210   N        5-ethyl-2-   240-244* 232-235*                                                 (1,3,4-thiadiazole)                                             ______________________________________                                    

                                      TABLE C                                      __________________________________________________________________________      ##STR9##                                   (Formula A.sub.5)                                                         m.p. (°C.)                       Cpd Y   Y.sup.1                                                                              Y.sup.2                                                                           R.sup.5        Z.sup.1                                                                             Z.sup.3                                                                          acid  Na salt                           __________________________________________________________________________     53  H   H     H  CH.sub.3       H    H 177-178                                                                              --                                54  H   H     H                                                                                  ##STR10##     F    H 159-160                                                                              --                                55  H   H     H                                                                                  ##STR11##     F    H 108-124                                                                              --                                56  H   H     H                                                                                  ##STR12##     F    H 158-164                                                                              --                                57  H   H     H                                                                                  ##STR13##     F    H 182-186                                                                              --                                58  H   H     H  CH.sub.3       F    H 206-214                                                                              --                                59  H   H     H                                                                                  ##STR14##     Cl   H 148-150                                                                              --                                60  H   H     H                                                                                  ##STR15##     Cl   H 168-170                                 61  H   H     H                                                                                  ##STR16##     Cl   H 150-152                                                                              --                                62  H   H     H                                                                                  ##STR17##     Cl   H 46-47 --                                63  OCH.sub.3                                                                          H     H  H              F    H 220-240                                                                              208*                              64  Cl  H     H  H              H    H 225                                     65  Cl  H     H  H              F    H 210-214*                                                                             200+                              66  H   OCH.sub.2 CH.sub.3                                                                   H  H              H    H 141-142                                 67  H   OCH.sub.2 CH.sub.3                                                                   H  H              F    H 135-136                                                                              233-235                           68  H   Cl    H  H              Cl   H 163-164                                                                              >330                              69  H   Cl    H  H              F    H 157-159                                                                              >320                              70  H   C.sub.6 H.sub.5                                                                      H  H              H    H 193-195                                                                              242-244+                          71  H   C.sub.6 H.sub.5                                                                      H  H              F    H 240-250                                                                              246-248+                          72  H   H     Cl H              H    H                                         73  H   H     Cl H              F    H 214-215+                                                                             >320                              74  H   C.sub.2 H.sub.5                                                                      H  H              F    H 178*  190-193*                          75  H   CH.sub.3                                                                             H  H              F    H 167-169*                                                                             228-230*                          76  CH.sub.3                                                                           H     H  H              F    H 186-188                                                                              214-216                           77  C.sub.2 H.sub.5                                                                    H     H  H              F    H 160-161                                                                              233-235                           78  H   H     CH.sub.3                                                                          H              F    H                                         79  H   H     C.sub.2 H.sub.5                                                                   H              F    H                                         80  OCH.sub.3                                                                          H     H                                                                                  ##STR18##     F    H       --                                81  Cl  H     H                                                                                  ##STR19##     F    H 118-120                                                                              --                                82  H   OCH.sub.2 CH.sub.3                                                                   H                                                                                  ##STR20##     F    H 150-152                                                                              --                                83  H   Cl    H                                                                                  ##STR21##     F    H 160-163                                                                              --                                84  H   C.sub.6 H.sub.5                                                                      H                                                                                  ##STR22##     F    H 197-198                                                                              --                                85  H   H     H  CH.sub.2OCOC(CH.sub.3).sub.3                                                                  F    H 173-175°                                                                      --                                86  H   H     H  CH.sub.2OCO- -nC.sub.3 H.sub.7                                                                C.sub.2 H.sub.5                                                                     H 103-105°                                                                      --                                162 H   H     H                                                                                  ##STR23##     Cl   Cl                                                                               187-190                                                                              --                                163 H   H     H                                                                                  ##STR24##     SCH.sub.3                                                                           H 133-134                                                                              --                                165 H   H     H                                                                                  ##STR25##     F    H 85-103                                                                               --                                166 H   H     H                                                                                  ##STR26##     F    H 137-150                                                                              --                                167 H   H     H                                                                                  ##STR27##     F    H 138-148                                                                              --                                168 H   H     H                                                                                  ##STR28##     F    H 149-150                                                                              --                                169 H   H     H                                                                                  ##STR29##     F    H 168-170                                                                              --                                170 H   H     H                                                                                  ##STR30##     F    H 160-161                                                                              --                                171 H   H     H                                                                                  ##STR31##     F    H       --                                172 H   H     H                                                                                  ##STR32##     Cl   H 173-177                                                                              --                                173 H   H     H                                                                                  ##STR33##     F    F 191-192                                                                              --                                __________________________________________________________________________

                  TABLE D                                                          ______________________________________                                          ##STR34##                (Formula A.sub.6)                                    Cpd.                     m.p.°                                          No.   W      W'     W"    W'"  Z.sup.1                                                                            acid    Na salt                             ______________________________________                                         87    CH     CH     CH    N    H   160-162+                                    88    CH     CH     CH    N    F   125-133*                                                                               198-199+                            89    CH     N      CH    CH   H   230-245                                     90    CH     N      CH    CH   F                                               91    CH     CH     N     CH   H   180-182+                                    92    CH     CH     N     CH   F                                               93    CH     N      CCl   N    H   165-167 230-240*                            94    CH     N      CCl   N    F                                               95    CH     N      CH    N    H   194-195*                                                                               214-216*                            96    CH     N      CH    N    F                                               97    N      CH     N     CH   H   196-198*                                                                               207-208+                            98    N      CH     N     CH   F                                               99    N      CH     CH    N    H   164-169+                                    100   N      CH     CH    N    F                                               ______________________________________                                    

                                      TABLE E                                      __________________________________________________________________________      ##STR35##                                              (Formula                                                                       A.sub.7)                                                                    m.p.                      Cpd Q' Q"   Q'"   R.sup.3                                                                             R.sup.5    X Z   Z.sup.1                                                                               Z.sup.2                                                                            Z.sup.3                                                                          acid  Na                  __________________________________________________________________________                                                                salt                105CH  S    CH    CH.sub.3                                                                            H          O H   H      H   H 238   270                 106CH  S    CH    CH.sub.3                                                                            H          O Cl  H      H   H 235   >290                107CH  S    CH    CH.sub.3                                                                            H          O H   Cl     H   H 258                       108CH  S    CH    CH.sub.3                                                                            H          O H   H      Cl  H 240   203                 109CH  S    CH    CH.sub.3                                                                            H          O H   Cl     H   Cl                                                                               210   240-                                                                           244                 110CH  S    CH    CH.sub.3                                                                            H          O H   F      H   H 252   222                 111CH  S    CH    CH.sub.3                                                                            H          O H   H      F   H 260   280                 112CH  S    CH    CH.sub.3                                                                            H          O H   OCH.sub.3                                                                             H   H 262   280                 113CH  CH   S     CH.sub.3                                                                            H          O H   H      H   H 258   223                 114CH  CH   S     CH.sub.3                                                                            H          O Cl  H      H   H 256   201-                                                                           209                 115CH  CH   S     CH.sub.3                                                                            H          O H   Cl     H   H 249   192-                                                                           203                 116CH  CH   S     CH.sub.3                                                                            H          O H   H      Cl  H 251   242                 117CH  CH   S     CH.sub.3                                                                            H          O H   Cl     H   Cl                                                                               216   242-                                                                           246                 118CH  CH   S     CH.sub.3                                                                            H          O H   F      H   H 255   239-                                                                           242                 119CH  CH   S     CH.sub.3                                                                            H          O H   H      F   H 261   235-                                                                           239                 120CH  CH   S     CH.sub.3                                                                            H          O H   OCH.sub.3                                                                             H   H 253   225                 121S   CH   CH    CH.sub.3                                                                            H          O H   H      H   H 170-171                                                                              232-                                                                           233                 122S   CH   CH    CH.sub.3                                                                            H          O H   Cl     H   H 174-175                                                                              223-                                                                           224                 123S   CH   CH    CH.sub.3                                                                            H          O H   Cl     H   Cl                                                                               207-208                                                                              210+                124S   CH   CH    CH.sub.3                                                                            H          O H   F      H   H 174-176                                                                              218-                                                                           220                 125S   CH   CH    CH.sub.3                                                                            H          O H   F      H   F 194-195                                                                              227-                                                                           229                 126CH  O    CH    CH.sub.3                                                                            H          O H   H      H   H 240   210+                127CH  O    CH    CH.sub.3                                                                            H          O H   Cl     H   H 256   235+                128CH  O    CH    CH.sub.3                                                                            H          O H   Cl     H   Cl                          129CH  O    CH    CH.sub.3                                                                            H          O H   F      H   H 253   225+                130CH  O    CH    CH.sub.3                                                                            H          O H   F      H   F                           131CH  CH   O     CH.sub.3                                                                            H          O H   H      H   H                           132CH  CH   O     CH.sub.3                                                                            H          O H   Cl     H   H                           133CH  CH   O     CH.sub.3                                                                            H          O H   Cl     H   Cl                          134CH  CH   O     CH.sub.3                                                                            H          O H   F      H   H                           135CH  CH   O     CH.sub.3                                                                            H          O H   F      H   F                           136O   CH   CH    CH.sub.3                                                                            H          O H   H      H   H                           137O   CH   CH    CH.sub.3                                                                            H          O H   Cl     H   H                           138O   CH   CH    CH.sub.3                                                                            H          O H   Cl     H   Cl                          139O   CH   CH    CH.sub.3                                                                            H          O H   F      H   H                           140O   CH   CH    CH.sub.3                                                                            H          O H   F      H   F                           141S   N    CH    CH.sub.3                                                                            H          O H   F      H   H 222+  202-                                                                           205*                142S   N    CH    CH.sub.3                                                                            H          O H   Cl     H   H 244-247                                                                              200-                                                                           206*                143CH  N    S     CH.sub.3                                                                            H          O H   F      H   H 208-210                                                                              268-                                                                           278                 144CH  N    S     CH.sub.3                                                                            H          O H   Cl     H   H                           174CH  S    N     CH.sub.3                                                                            H          O H   F      H   H 187-189                                                                              236-                                                                           240+                175N   N    S     CH.sub.3                                                                            H          O H   F      H   H 205-207+                                                                             220-                                                                           230+                176CH  N    O     CH.sub.3                                                                            H          O H   F      H   H 238-240+                                                                             265-                                                                           290+                177CNO.sub.2                                                                          S    CH    CH.sub.3                                                                            H          O H   H      H   H 200*+                     178CNO.sub.2                                                                          S    CH    CH.sub.3                                                                            H          O H   F      H   H 205*+                     179S   N    CH    CH.sub.3                                                                            H          O H   H      H   H 199-204                                                                              199#                180S   N    CH    CH.sub.3                                                                            H          O H   Cl     H   Cl                                                                               235-237+                                                                             198                 181S   N    CH    CH.sub.3                                                                            H          O H   F      H   F 241-243+                                                                             238-                                                                           239+                182S   N    CH    CH.sub.3                                                                            H          S H   Cl     H   H 188-189+                                                                             167-                                                                           172+                183S   N    CH    CH.sub.3                                                                            H          S H   F      H   H 189-196+                                                                             164-                                                                           169+                184S   N    CH    CH.sub.3                                                                            H          O H   CH.sub.3                                                                              H   H 208#,                                                                                204-                                                                           208                 185S   N    CH    CH.sub.3                                                                            H          O H   CH.sub.2 CH.sub.3                                                                     H   H 201#,                                                                                198-                                                                           201                 186S   N    CH    CH.sub.3                                                                            H          O H   Br     H   H       197-                                                                           204+                187S   N    CH    CH.sub.3                                                                            H          O H   I      H   H       199-                                                                           205+                188S   N    CH    CH.sub.2 CH.sub.3                                                                   H          O H   F      H   H 182-183                                                                              179-                                                                           183                 189S   N    CH    CH.sub.2 CH.sub.3                                                                   H          O H   Cl     H   H 178-183                                                                              172-                                                                           178*                190S   N    CH    CH.sub.3                                                                             ##STR36## O H   F      H   H       --                  191S   N    CH    CH.sub.3                                                                             ##STR37## O H   H      H   H 163-171                                                                              --                  192S   N    CH    CH.sub.3                                                                             ##STR38## O H   F      H   H 159-169                                                                              --                  193S   N    CH    CH.sub.3                                                                             ##STR39## O H   Cl     H   H 155-165                                                                              --                  194S   N    CH    CH.sub.3                                                                             ##STR40## O H   Cl     H   Cl                                                                               183-194                                                                              --                  211S   N    CH    CH.sub.3                                                                            C.sub.6 H.sub.5                                                                           O H   F      H   H                           212S   N    CH    CH.sub.3                                                                            CH.sub.2 CF.sub.3                                                                         O H   F      H   H 200-201                   213S   N    CH    CH.sub.3                                                                            H          O H   OCHF.sub.2                                                                            H   H                           214S   N    CH    CH.sub.3                                                                            H          O H   OCF.sub.3                                                                             H   H                           215S   N    CH    CH.sub.3                                                                            H          O H   OCF.sub.2 CHF.sub.2                                                                   H   H                           216 CH O    N     CH.sub.3                                                                            H          O H   F      H   H 252-253+                  217S   N    CH    CH.sub.3                                                                             ##STR41## O H   F      H   H                           218S   N    CH    CH.sub.3                                                                             ##STR42## O H   F      H   H                           219N   NCH.sub.3                                                                           CH    CH.sub.3                                                                            H          O H   F      H   H 290-293+                                                                             250-                                                                           260+                222S   N    CH    CH.sub.3                                                                            H          O H   OCF.sub.3                                                                             H   H 218*  223*                223S   N    CH    CH.sub.3                                                                            H          O H   OCHF.sub.2                                                                            H   H 204*  215*                224S   N    CH    CH.sub.3                                                                            H          O H   H      F   H 243*  195-                                                                           201*                225S   N    CH    CH.sub.3                                                                            H          O Cl  H      H   H 218*  208-                                                                           212                 226S   N    CH    CH.sub.3                                                                            H          O H   H      Cl  H 249-253*                                                                             203-                                                                           209                 227S   N    CH    CH.sub.3                                                                            H          O H   H      CH.sub.3                                                                           H 237-239                                                                              216-                                                                           226+                228S   N    CH    CH.sub.3                                                                            H          O H   OCH.sub.3                                                                             H   H 199*  208-                                                                           210                 229S   N    CH    CH.sub.3                                                                            H          O CH.sub.3                                                                           H      H   H 276-278                                                                              194-                                                                           200                 230S   N    CH    CH.sub.3                                                                            H          O H   H      OCH.sub.3                                                                          H 195*  193-                                                                           203                 231S   N    CH    CH.sub.3                                                                            H          O OCH.sub.3                                                                          H      H   H 214*  221*                232S   N    CH    CH.sub.3                                                                            H          O F   H      H   H 216*  246*                233S   N    CH    CH.sub.3                                                                            H          O H   CH.sub.3                                                                              F   H 222*  206-                                                                           220*                234S   N    CH    CH.sub.3                                                                            H          O H   CF.sub.3                                                                              H   H 276   234-                                                                           235                 235S   N    CCH.sub.3                                                                            CH.sub.3                                                                            H          O H   F      H   H 189-192*                                                                             255                 236S   N    CCl   CH.sub.3                                                                            H          O H   F      H   H 209-210*                                                                             260-                                                                           268                 237S   N    COCH.sub.3                                                                           CH.sub.3                                                                            H          O H   F      H   H       193-                                                                           195*                238S   N    CH    CH.sub.3                                                                            CH.sub.2 CF.sub.3                                                                         O H   Cl     H   H 178-182                                                                              --                  239S   N    CH    CH.sub.3                                                                            C.sub.6 H.sub. 5                                                                          O H   Cl     H   H 206-208                                                                              --                  __________________________________________________________________________

                                      TABLE F                                      __________________________________________________________________________      ##STR43##                          (formula A.sub.8)                          Cpd.                             m.p.°                                  No. R.sup.5   R.sup.9 Z.sup.1                                                                           m.p.°                                                                           Na salt                                                                             NH.sub.4 salt                            __________________________________________________________________________     151 H         CH.sub.3                                                                               H  140-142*                                                                               110-120#                                                                       140*                                          151(A)                                                                             CH.sub.3  CH.sub.3                                                                               H  156-159 --   --                                       152 H         CH.sub.3                                                                               Cl 70#     108#,                                                                  100-110*                                                                               134*                                          195 H         CH.sub.3                                                                               F  80-83   155+ 87-90                                    196 H         CH.sub.2 CH.sub.3                                                                      F  71-73   140-143                                       197 H         CH.sub.2 CHCH.sub.2                                                                    F  126-127 157-160                                       198 H         CH.sub.2C.sub.6 H.sub.5                                                                F  158-159 115-117                                       199 H         CH.sub.3                                                                               CH.sub.3                                                                          88+     64#, 119                                      200 CH.sub.2 OC(O)C(CH.sub.3).sub. 3                                                         CH.sub.3                                                                               H  75-78#  --   --                                       201 CH.sub.2 OC(O)C(CH.sub.3).sub.3                                                          CH.sub.3                                                                               Cl (viscous yellow                                                                        --   --                                                                oil)                                                  202 CH.sub.2 OC(O)C(CH.sub.3).sub.3                                                          CH.sub.3                                                                               F  (oil)   --   --                                       __________________________________________________________________________

INTERMEDIATE COMPOUNDS EXAMPLE 21

A solution of 3-fluorophenyl isocyanate (5.0 g, 36.0 mmol) in 20 ml of toluene is added to hydrazine hydrate (2.1 g, 42.0 mmol) in 70 ml of dioxane, maintaining the temperature of the reaction at less than 12°. After 2 hours, the reaction is filtered and the solvent is removed from the filtrate by rotoevaporation to give the white solid, 4-(3-fluorophenyl)semicarbazide.

Following the above procedure, each of 4-phenylsemicarbazide,-4-(3-chlorophenyl)semicarbazide and 4-(3-methylphenyl)semicarbazide is prepared from the corresponding isocyanate and hydrazine hydrate.

EXAMPLE 22

To a solution of 2-fluoroaniline (11.1 g, 100.0 mmol) in 100 ml of dry ether cooled in an ice bath is added ethyl chloroformate (7.1 ml, 8.1 g, 75.0 mmol). After addition, the mixture is allowed to warm to RT and is stirred at RT for 3 hours. Then a 10% sodium hydroxide solution (54 ml, 2.8M, 150.0 mmol) is added, followed by another 7.1 ml of ethyl chloroformate. The mixture is stirred at RT for 3 hours, and is then poured into water and ether. The organic layer is separated, washed with 5% HCl and with brine, and dried. The solvent is removed to give ethyl N-(2-fluorophenyl)carbamate.

A mixture of ethyl N-(2-fluorophenyl)carbamate (8.3 g, 45.4 mmol) and hydrazine hydrate (13.6 g, ca. 14 ml) in 40 ml of absolute ethanol is heated to reflux. After 3 days, the reaction mixture is concentrated, and the solid is filtered, washed with water and with ether and dried to give 4-(2-fluorophenyl)semicarbazide.

Following the above procedures, each of 4-(3,5-dichlorophenyl)semicarbazide, 4-(3,5-difluorophenyl)semicarbazide, 4-(2-pyridyl)semicarbazide and 4-(3-pyridyl)semicarbazide is prepared from hydrazine hydrate and the corresponding substituted carbamate.

EXAMPLE 23

A mixture of 3-chloro-2-methylphenylurea (5.0 g, 27.0 mmol), hydrazine hydrate (4.0 g, 80.0 mmol), 4 ml of water and 30 ml of ethanol is heated to reflux for 12 hours. The reaction mixture is then cooled and poured onto ice. A white precipitate forms, which is collected by filtration, washed with water and dried. The resulting solid is dissolved in hot ethanol and conc. HCl is added. The mixture is cooled and the resulting white solid precipitate is collected by filtration, washed with ethanol, and dried under vacuum to give 4-(3-chloro-2-methylphenyl)semicarbazide hydrochloride.

EXAMPLE 24

Sixteen grams (88.4 mmol) of 2-acetylnicotinic acid N-oxide (J. Chem. Soc., 1961, 5216) is added to a solution of sodium hydroxide (3.5 g, 88.4 mmol) in 300 ml of water. The pH is adjusted to 9 by the addition of 6N NaOH, and 10% palladium on carbon (1.6 g) is added. The mixture is then hydrogenated until a 20% excess of hydrogen is taken up. The reaction mixture is filtered through Celite, and the pH of the filtrate is adjusted to 2.5 with 6N HCL. The solvent is removed by rotoevaporation and the residue is taken up in methanol. The mixture is filtered and the filtrate is evaporated to give a pale beige solid, 2-acetylnicotinic acid.

EXAMPLE 25

An ethereal solution of diazomethane (excess) is added to a stirred suspension of ethyl 1,6-dihydro-2-acetyl-6-oxonicotinate (2.20 g, 10.5 mmol) in 10 ml of ether. The ether and excess diazomethane are removed under vacuum, and the crude product is purified by column chromatography, eluting with 30% ethyl acetate/hexane to give ethyl 2-acetyl-6-methoxynicotinate.

Ethyl 2-acetyl-6-methoxynicotinate (0.92 g, 4.13 mmol) in 20 ml of methanol is stirred with lithium hydroxide monohydrate (0.18 g, 4.20 mmol) in 3 ml of water. After 1.5 hours, the water and methanol are removed by rotoevaporation The residue is dissolved in chloroform and 3N hydrochloric acid. The aqueous phase is extracted with chloroform and the combined organic extracts are washed with brine and dried and the solvent is removed to give 2-acetyl-6-methoxynicotinic acid.

EXAMPLE 26

To sodium balls (4.78 g, 208.0 mmol) under N₂ is added 65 ml of ethanol at a rate to maintain reflux and with stirring. To this solution of sodium ethoxide in ethanol is added ethyl propionylacetate (30.0 g, 208.0 mmol) in 30 ml of ethanol. After 30 min., 3-bromopropionitrile (9.38 g, 70.0 mmol) is added dropwise, and the reaction mixture is stirred at RT overnight. The resulting solid is removed by vacuum filtration Excess ethanol is removed by rotoevaporation, and the residue is poured into ether and 5% hydrochloric acid The organic phase is separated, washed to neutrality with brine and dried and the solvent is removed to give, after distillation, ethyl 2-(2-cyanoethyl)propionylacetate.

To a well-stirred solution of 8 ml of conc. hydrochloric acid cooled in an ice bath is added the above propionylacetate (6.7 g, 34.0 mmol). The bath is removed after 30 min., and the reaction mixture is warmed to ca. 25°. The mixture is stirred for another 1.5 hours and then poured onto ice. The solid is separated by vacuum filtration and dried overnight to give ethyl 1,4,5,6-tetrahydro-2-ethyl-6-oxonicotinate.

A mixture of the above oxonicotinate (2.7 g, 13.7 mmol) and 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) in 100 ml of dioxane is heated to reflux overnight, after which the dioxane is removed by rotoevaporation The residue is dissolved in chloroform and extracted with sat. sodium bicarbonate. The organic fraction is washed with brine and dried and the solvent is removed. The resulting solid is triturated with small volumes of ether/hexane. The solid left undissolved is dried to give ethyl 1,6-dihydro-2-ethyl-6-oxonicotinate.

A mixture of the above 1,6-dihydrooxonicotinate (1.33 g, 6.82 mmol) and phosphorus oxychloride (1.83 ml, 3.06 g, 20.0 mmol) is heated to 120° for 3.5 hours. The reaction mixture is poured onto ice and extracted with chloroform. The combined organic phases are washed with brine and dried and the solvent is removed to give, after purification by column chromatography, ethyl 6-chloro-2-ethylnicotinate.

A solution of ethyl 6-chloro-2-ethylnicotinate (1.0 g, 4.7 mmol), N-bromosuccinimide (0.85 g, 4.8 mmol) and benzoyl peroxide (10 mg) in 10 ml of carbon tetrachloride is heated to reflux while irradiated with a floodlamp for 3 hours. The reaction mixture is cooled and the solid succinimide is removed by filtration. The solid is washed several times with carbon tetrachloride and the filtrate is stripped by rotoevaporation to give ethyl 6-chloro-2-(1-bromoethyl)nicotinate.

Sodium bicarbonate (0.42 g, 5.0 mmol) is added to the above bromide (1.33 g, 4.55 mmol) in 13 ml of dry DMSO. The mixture is heated at 90° for 1.75 hours, then cooled, worked up and dried. The solvent is removed and the crude product is purified by prep. TLC to give ethyl 2-acetyl-6-chloronicotinate. Following the procedure of Example 11, the ethyl 2-acetyl-6-chloronicotinate is reacted with lithium hydroxide monohydrate to give 2-acetyl-6-chloronicotinic acid.

EXAMPLE 27

2-Ethoxy-1-dimethylamino-3-dimethylimonio-1-propene perchlorate (2.00 g, 3.56 mmol) is dissolved in 10 ml of DMF, and ethyl propionylacetate (0.56 g, 3.90 mmol) and potassium carbonate (0.50 g, 3.56 mmol) are added. The reaction mixture is heated at 85°-90° for 1 hour, then cooled to RT. A mixture of 5 ml of ammonium hydroxide in 15 ml of ethanol is added and the reaction is stirred at RT for 2 hours. The resulting mixture is poured onto water and extracted with ethyl acetate, dried and concentrated to give, after purification by flash chromatography, ethyl 5-ethoxy-2-ethylnicotinate. Following the procedure of Example 12, the above nicotinate is brominated by reaction with N-bromosuccinimide, and the resulting bromide is reacted with sodium bicarbonate in DMSO to give ethyl 2-acetyl-5-ethoxynicotinate.

Following the procedure of Example 25, the above nicotinate is hydrolyzed to 2-acetyl-5-ethoxynicotinic acid.

EXAMPLE 28

Ammonia is bubbled into a solution of 2-ethyl-3-methoxycarbonyl-4-pyranone (6.5 g) in 70 ml of ethanol, cooled in an acetone/ice bath, for 1 hour. The resulting solution is then heated to reflux for 1.5 hours, cooled and concentrated to give ethyl 1,4-dihydro-2-ethyl-4-oxonicotinate.

A mixture of the above oxonicotinate (6.6 g) and phosphoryl chloride (50 ml) is heated at 120° for 2 hours, then poured onto ice, and diluted and extracted with ethyl acetate. The aqueous layer is cooled to below 50° and treated with 50% sodium hydroxide to pH 7. After cooling to 25°, it is extracted with ethyl acetate. The combined organic layers are dried, concentrated and purified by flash chromatography to give ethyl 4-chloro-2-ethylnicotinate.

A mixture of the above ethylnicotinate (5.45 g), N-bromosuccinimide (NBS) (5.50 g) and 2,2'-azobis(2-methylpropionitrile) (AIBN) (0.40 g) in carbon tetrachloride (50 ml) is heated under reflux for 2 hours, then cooled, filtered and concentrated in vacuo to give ethyl 4-chloro-2-(1-bromoethyl)nicotinate.

A mixture of ethyl 4-chloro-2-(1-bromoethyl)nicotinate (7.45 g) and sodium bicarbonate (4.00 g) in 50 ml of DMSO is heated at 120°, under nitrogen, for 2 hours, after which it is cooled, diluted with water, filtered and extracted with ether. The combined organic layers are washed with water and concentrated. The residue is taken into ethyl acetate, washed with brine, dried, concentrated and purified by flash chromatography to give 4-chloro-7-methylfuro-[3,4-b]-pyridin-5-(7H)-one, which is then reacted with N-bromosuccinimide and 2,2'-azobis(2-methylpropionitrile), as above, to give 7-bromo-4-chloro-7-methylfuro-[3,4-b]-pyridin-5-(7H)-one.

A solution of lithium hydroxide monohydrate (0.27 g) in 20 ml of water is added to a slurry of the above lactone (1.20 g) in 40 ml of ethanol. The mixture is stirred at RT for 2.5 hours, and is then concentrated in vacuo. The residue is partitioned in 2N sulfuric acid and ethyl acetate, extracted with ethyl acetate, washed with brine, dried and purified to give 2-acetyl-4-chloronicotinic acid.

EXAMPLE 29

A mixture of sodium acetate (14.76 g, 180.0 mmol) and acetic anhydride (150 ml) is heated, under N₂, to 120° for 10 min., and is then chilled to 10°. 2-Ethyl-2-propenal dimethylhydrazone (11.36 g, 90.0 mmol) is added, followed by addition of bromomaleic anhydride (16.41 g, 92.7 mmol) and the reaction mixture is stirred at 10° for ca. 1 hour. The mixture is then diluted with methylene chloride and filtered, and the solid is rinsed with methylene chloride until colorless. The filtrate is concentrated to remove the solvent and to give 1,4-dihydro-1-dimethylamino-5-ethyl-2,3-pyridinedicarboxylic anhydride.

The above anhydride is dissolved in THF, and 100 ml of 2M HCl is added. The mixture is stirred and the THF is distilled off. The residue is recrystallized from THF to give 5-ethyl-2,3-pyridinedicarboxylic acid.

A mixture of the above carboxylic acid (3.0 g, 15.37 mmol) and acetic anhydride (15 ml) is heated until the acid is dissolved. The mixture is then concentrated under vacuum, and the residue is dissolved in ether, stirred, filtered, concentrated and dried to give 5-ethyl-2,3-pyridinedicarboxylic anhydride.

Following the procedure of Example 30, 5-ethyl-2,3-pyridinedicarboxylic anhydride is treated with lithium methylsulfonylmethyl(methyl)cuprate(I) to give 2-acetyl-5-ethylnicotinic acid.

EXAMPLE 30

A mixture of 2-methoxycarbonylnicotinic acid (4.0 g) and thionyl chloride (30 ml) is heated under reflux until homogeneous. The remaining thionyl chloride is distilled off in vacuo to give 2-methoxycarbonylnicotinoyl chloride.

Lithium methylsulfonylmethyl(methyl)cuprate(I) is chilled to -78°, and 2-methoxycarbonylnicotinoyl chloride (3.2 g, 16.0 mmol) is slowly added, keeping the temperature at -65 to -70. The mixture is stirred at -78° for 1 hour, after which aq. ammonium chloride is added. The mixture is warmed to RT, poured into water and ethyl acetate and extracted with ethyl acetate. The combined organic phases are dried and reduced and the product is purified by prep. TLC to give methyl 3-acetyl-2-pyridinecarboxylate.

To methyl 3-acetyl-2-pyridinecarboxylate (1.86 g) in 20 ml of ethanol is added lithium hydroxide monohydrate (10 mmol) in 20 ml of hot water. After 1 hour, conc. hydrochloric acid (1 ml) is added, and the mixture is reduced under vacuum. The resulting solid is extracted with hot methylene chloride, and the residue is stirred with 15 ml of THF for 1 hour at 60°, then filtered and dried to give 3-acetyl-2-pyridinecarboxylic acid.

EXAMPLE 31

Following the procedure of Example 30, 4-methoxycarbonylnicotinic acid is reacted with thionyl chloride to give 4-methoxycarbonylnicotinoyl chloride. A slurry of the above chloride (22.7 mmol) in 100 ml of monoglyme (ethylene glycol dimethyl ether) is added to a chilled mixture of the sodium salt of diethyl malonate (2.2 eq.) in monoglyme. The mixture is allowed to warm to RT and is stirred at RT for 4 hours. Aq. sodium bicarbonate is added and the mixture is extracted with ether. It is then acidified to pH 2-3 and again extracted with ether. The combined organic phases of the acid layer are dried, filtered and concentrated to give methyl 3-(diethyl malonylcarbonyl)isonicotinate, which is then reacted with lithium hydroxide monohydrate and then hydrochloric acid to give 3-acetylisonicotinic acid.

EXAMPLE 32

A mixture of diethyl 3-oxofuro-(3,4-c)pyridin-1-(3H)-ylidene malonate (3.21 g, 11.0 mmol), 50% sodium hydroxide (4.0 g, 50.0 mmol) and 25 ml of water is heated to 120° for 4 hours. Hydrochloric acid is added until the mixture is acidic, after which it is heated for 5 min. and then cooled to RT and reduced. The residue is extracted with methylene chloride, with methylene chloride/ethanol (9:1) and with hot ethanol. The combined organic extracts are reduced and extracted with THF/methanol. The residue is reduced to give 4-acetylnicotinic acid.

EXAMPLE 33

A mixture of ethyl 5-acetyl-2-hydroxy-4-pyrimidinecarboxylate (2.91 g, 13.8 mmol), phosphoryl chloride (11 ml, 118.0 mmol) and diethylaniline (3 ml, 18.0 mmol) is heated to reflux under N₂ for 45 min, after which it is cooled to RT and worked up. The residue is distilled, then dissolved in a small amount of methylene chloride and set aside to crystallize. The solid is then filtered, rinsed with methylene chloride and dried to give ethyl 5-acetyl-2-chloro-4-pyrimidinecarboxylate.

Following the procedure of Example 30, ethyl 5-acetyl-2-chloro-4-pyrimidinecarboxylate is reacted with lithium hydroxide monohydrate to give the corresponding lithium salt and then with hydrochloric acid to give 5-acetyl-2-chloro-4-pyrimidinecarboxylic acid.

EXAMPLE 34

To a mixture of the lithium salt of 5-acetyl-2-chloro-4-pyrimidinecarboxylic acid (1.1 g, 4.90 mmol) and sodium bicarbonate (0.5 g, 5.95 mmol) in 20 ml of water is added 10% palladium on carbon (0.1 g), and the reaction mixture is kept under H₂ overnight. It is then acidified with 1M hydrochloric acid (6 ml) and concentrated. The resulting solid is filtered, rinsed with water and dried to give 5-acetyl-4-pyrimidinecarboxylic acid.

EXAMPLE 35

Silica (Silica 60; 10 g) is added to 40 ml of methylene chloride. Sulfuric acid (0.15 g) and water (0.85 g) are added and the suspension is stirred for 5 min. until the water is absorbed. Ethyl 4-(1,1-diethoxyethyl)-5-pyrimidinecarboxylate is added and the mixture is stirred at RT for ca. 7 hours. The reaction mixture is filtered and rinsed with methylene chloride and with ethanol. The combined organic phases are reduced to give ethyl 4-acetyl-5-pyrimidinecarboxylate.

Following the procedure of Example 30, 4-acetyl-5-pyrimidinecarboxylate is reacted with lithium hydroxide monohydrate and with hydrochloric acid to give 4-acetyl-5-pyrimidinecarboxylic acid.

EXAMPLE 36

Following the procedure of Example 30, 3-methoxycarbonyl-2-pyrazinecarboxylic acid is reacted with thionyl chloride to make the corresponding acid chloride, which is then reacted with lithium methylsulfonylmethyl(methyl)cuprate (I) to give methyl 3-acetyl-2-pyrazinecarboxylate. This carboxylate is reacted with lithium hydroxide monohydrate and with hydrochloric acid to give 3-acetyl-2-pyrazinecarboxylic acid.

EXAMPLE 37

At 0°, a solution of anhydrous ferric chloride (2.7 g, 17.0 mmol) in 50 ml of nitromethane is added portionwise with stirring over a period of 5 hours to a mixture of 3-bromofuran (25.0 g, 170.0 mmol) and acetic anhydride (20.4 g, 200.0 mmol) in 50 ml of nitromethane. After addition is completed, the resulting mixture is stirred at RT for 17 hours and is then evaporated in vacuo. The residue is taken up in 200 ml of diethyl ether, treated with 3.0 g of activated charcoal and filtered. The filtrate is washed with 5% sodium bicarbonate and dried and the solvent is removed by rotoevaporation to give, after purification, 2-acetyl-3-bromofuran. A well-stirred mixture of 2-acetyl-3-bromofuran (13.7 g, 72.0 mmol), ethylene glycol (5.9 g, 94.0 mmol), p-toluenesulfonic acid (p-TSOH; 20 mg) and benzene (50 ml) is refluxed for 9 hours, after which additional ethylene glycol (1.8 g, 29.0 mmol) and p-TSOH (5 mg) is added and the refluxing is continued a further 16 hours. The reaction mixture is then washed with sat. sodium bicarbonate and with water and is dried. The solvent is removed by rotoevaporation to give 2-(3-bromo-2-furyl)-2-methyl-1,3-dioxolane. To a solution of 1.6M butyllithium in hexane (38 ml) and dry diethylether (40 ml), under N₂, is added dropwise with stirring a solution of the above dioxolane (11.18 g, 48.0 mmol) in 40 ml of ether, keeping the temperature below -68°. After addition is completed, the mixture is stirred for 30 min. at -70°, and then a slurry of CO₂ (50.0 g) in 100 ml of dry diethyl ether is added. The mixture is kept at -65° for 15 min. and is then allowed to warm to 10°. Water is added, followed by 10% sodium carbonate. The phases are separated and the organic phase is extracted. The combined aqueous phases are acidified with conc. HCl and extracted with ether. The organic phases are combined and dried and the solvent is removed by rotoevaporation. The resulting product is suspended in 5% HCl (85 ml) and stirred at RT for 2 hours, then extracted with ether and the combined ether phases are dried and evaporated to dryness. The crude product is purified to give 2-acetyl-3-furancarboxylic acid.

EXAMPLE 38

Ethyl 3-amino2-pentenoate (20 g) in 45 ml DMF is chilled to -78°. Phosphorus oxychloride (25.7 g) is added, keeping the temperature between -10 and -30°. A solid forms and the mixture is then diluted with 12 ml methylene chloride. The resulting mixture is rapidly added to a chilled solution of 51 gm sodium sulfide nonahydrate in 150 ml water. Methylene chloride is added to the orange mixture, and the mixture is stirred 1 hr at R.T. 12.5% Agueous sodium hypochloride (98ml) is added, and is backwashed with water and with aqueous sodium thiosulfate, dried, filtered and stripped. The residue is distilled to yield ethyl 3-ethyl-4-isothiazolecarboxylate.

EXAMPLE 39

Following generally the procedure of Example 28, ethyl 3-ethyl-4-isothiazolecarboxylate is reacted with NBS and benzoyl peroxide to give ethyl 3-(1-bromoethyl)-4-isothiazolecarboxylate, which is then reacted with sodium bicarbonate and DMSO and the resulting ethyl 3-acetyl-4-isothiazolecarboxylate is treated with lithium hydroxide monohydrate to yield 3-acetyl-4-isothiazolecarboxylic acid.

EXAMPLE 40

Following the procedure of Example 28, methyl 4-ethyl-5-thiazolecarboxylate is reacted with NBS and AIBN to give methyl 4-(1-bromoethyl)-5-thiazolecarboxylate, which is then reacted with sodium bicarbonate, or alteratively with potassium carbonate, and DMSO and the resulting methyl 4-acetyl-5-thiazolecarboxylate is treated with lithium hydroxide monohydrate to yield 4-acetyl-5-thiazolecarboxylic acid.

COMPOSITION EXAMPLES EXAMPLE 41

A. Water dispersible powder

The sodium salt or the isopropylammonium salt of compound 4 is dissolved to the desired percentage concentration in water containing 0.5% surfactant (e.g., a 1:1:1 mixture of sorbitan monolaurate:polyoxyethylene[20]sorbitan monolaurate:polyoxyethylene[20]sorbitan trioleate).

B. Suspension concentrate - 26%

    ______________________________________                                         sodium salt of cpd. 30                                                                              26%                                                       propylene glycol     73%                                                       octyl phenoxypoly[ethylene-                                                                          1%                                                       oxy]ethanol                                                                    ______________________________________                                    

The above components are mixed and wet-milled to 5-10 micron particle size.

C. Wettable powder - 50%

    ______________________________________                                         sodium salt of cpd. 30                                                                             50%                                                        sodium lignosulfonate                                                                               4%                                                        sodium dialkylnaphthalene                                                                           1%                                                        sulfonate                                                                      kaolin              45%                                                        ______________________________________                                    

The above components are mixed and wet-milled. The resulting mixture is added to water for spraying.

BIOLOGICAL ACTIVITY EXAMPLE 42

Pre-emergent herbicidal activity of selected componds of the present invention was determined as follows: Seeds of selected weeds were planted and the soil was drenched with a solution of water (17%), surfactant (0.17%) and the test compound at a rate equivalent to 10 lb/acre. Scoring was made two weeks after treatment. The grasses (GR) green foxtail, watergrass, shattercane and wild oats and the broadleafs (BL) annual morning glory, mustard, nightshade and velvetleaf were treated. The average pre-emergent activity of the compounds is presented in Table G below.

EXAMPLE 43

Post-emergence herbicidal activity of selected compounds of the present invention was tested as follows: Seedlings of selected weeds were sprayed with a solution of water/acetone (1:1), surfactant (0.5%) and the test compound at a rate equivalent to 10 lb/acre. Scoring was made two weeks after spraying. The grasses (GR) green foxtail, watergrass, shattercane and wild oats and the broadleafs (BL) annual morning glory, mustard, soybean and velvetleaf were treated. The average post-emergent activity of the compounds are presented in Table G below.

                  TABLE G                                                          ______________________________________                                         % Herbicidal Activity at 10 lb/Acre                                                           Pre           Post                                              Compound No.     GR     BL       GR   BL                                       ______________________________________                                         1                91     86       48   61                                       Na salt of 1     88     93       47   62                                       3                96     90       58   75                                       Na salt of 3     93     89       63   81                                       4                91     91       72   85                                       Na salt of 4     94     89       81   85                                       NH.sub.4 salt of 4                                                                              92     92       77   78                                       isoprop NH.sub.3 salt of 4                                                                      77     80       61   77                                       diisoprop NH.sub.3 salt of 4                                                                    82     80       63   80                                       22               58     58       30   71                                       Na salt of 22    53     73       20   56                                       23               75     63       53   70                                       Na salt of 23    68     80       66   73                                       24               92     86       55   76                                       Na salt of 24    85     82       63   75                                       25               90     68       68   81                                       Na salt of 25    79     90       66   85                                       30               96     87       78   86                                       Na salt of 30    100    89       83   90                                       31               87     83       80   87                                       Na salt of 31    96     100      71   86                                       32               92     95       90   95                                       Na salt of 32    96     94       86   90                                       55               80     80       76   82                                       57               85     90       63   85                                       60               85     80       71   78                                       61               82     81       67   81                                       110              88     76       --   --                                       Na salt of 110   81     80       60   80                                       ______________________________________                                     

What is claimed is:
 1. A compound of the following formula: ##STR44## each of R³ and R⁴ is independently hydrogen or C₁₋₈ alkyl; R⁵ is hydrogen; C₁₋₈ alkyl; C₁₋₈ haloalkyl; C₂₋₁₀ alkoxyalkyl; unsubstituted phenyl; phenyl substituted at one to three of the ring carbon atoms with a group selected from C₁₋₈ alkyl, C₁₋₈ haloalkyl, C₁₋₈ alkoxy, C₁₋₈ haloalkoxy or halogen; alkali cation; alkali earth cation; ammonium cation, unsubstituted or substituted by a C₁₋₂₀ alkyl, di-C₁₋₂₀ alkyl, tri-C₁₋₂₀ alkyl, tetra-C₁₋₂₀ alkyl, hydroxy-C₁₋₅ alkyl, di(hydroxy-C₁₋₅ alkyl), tri(hydroxy-C₁₋₅ alkyl), C₁₋₅ alkoxy-C₁₋₅ alkyl, hydroxy-C₁₋₅ alkoxy-C₁₋₅ alkyl or C₁₋₈ alkoxycarbonyl-C₁₋₅ alkyl group; phosphonium cation; tri-C₁₋₈ alkylsulfonium cation; tri-C₁₋₈ alkylsulfoxonium cation; or the group ##STR45## each of R⁶ and R⁹ is C₁₋₈ alkyl, C₂₋₈ alkenyl, phenyl or benzyl; each of R⁷ and R⁸ is independently hydrogen or C₁₋₈ alkyl; or R⁷ and R⁸ are taken together to form a lower alkylene bridge of three to six carbon atoms, optionally including one moiety selected from the group of O, S or NH in the ring;R¹⁰ is the group ##STR46## each of R¹¹ and R¹² is independently or C₁₋₈ alkyl or C₂₋₁₀ alkoxyalkyl; R¹³ is hydrogen or C₁₋₈ alkyl; Q is oxygen, sulfur or N-R¹³ ; W is nitrogen; each of X and X' is independently oxygen or sulfur; and each of Y, Z, Z¹, Z² and Z³ is independently hydrogen, C₁₋₈ alkyl, C₁₋₈ haloalkyl, C₁₋₈ alkoxy, C₁₋₈ haloalkoxy, C₂₋₈ alkenyloxy, C₂₋₈ haloalkenyloxy, C₂₋₈ alkynyloxy, phenyl, phenoxy, C₁₋₈ alkylthio, hydroxy, halogen, nitro, cyano, amino, C₁₋₈ alkylamino or dialkylamino.
 2. A compound of the following formula, according to claim 1: ##STR47##
 3. A compound according to claim 2 wherein R³ is methyl or ethyl; and R⁴ is hydrogen, methyl or ethyl.
 4. A compound according to claim 3 wherein Z is hydrogen, methyl, methoxy, ethyl, bromo, chloro, fluoro, iodo, trifluoromethyl or trifluoromethoxy; and Z¹ hydrogen, chloro, fluoro, methyl or methoxy.
 5. A compound according to claim 4 wherein X is oxygen
 6. A compound according to claim 5 wherein R⁵ is hydrogen, sodium cation, ammonium cation, C₁₋₂₀ alkylammonium cation, di-C₁₋₅ alkylammonium cation, hydroxy-C₁₋₅ alkylammonium cation, di-(hydroxy-C₁₋₅ alkyl)ammonium cation, hydroxy-C₁₋₅ alkoxy-C₁₋₅ alkylammonium cation or the group ##STR48##
 7. A compound according to claim 6 wherein R³ is methyl; R⁴ is hydrogen; R¹¹ is hydrogen, methyl, ethyl or sec-butyl;; and R¹² is hydrogen, methyl, ethyl, n-propyl, sec-butyl or tert-butyl.
 8. A compound according to claim 7 wherein R⁵ is hydrogen, sodium cation, isopropylammonium cation, tetradecylammonium cation, 2-hydroxyethylammonium cation, di-2-hydroxyethylammonium cation, 2-(2-hydroxyethoxy)ethylammonium action, butyryloxymethyl, pivaloyloxymethyl or 1-(propionyloxy)ethyl.
 9. A compound according to claim 8 wherein Z is hydrogen and Z¹ is hydrogen.
 10. A compound according to claim 8 wherein Z is 3-chloro or 3-fluoro and Z¹ is hydrogen.
 11. A compound according to claim 10 wherein Z is 3-fluoro.
 12. A compound according to claim 10 wherein Z is 3-chloro.
 13. A compound according to claim 8 wherein Z is 3-chloro or 3-fluoro and Z¹ is 5-chloro or 5-fluoro.
 14. A compound according to claim 13 wherein Z is 3-chloro and Z¹ is 5-chloro.
 15. A compound according to claim 13 wherein Z is 3-fluoro and Z¹ is 5-fluoro.
 16. A method for combatting weeds which comprises treating said weed or its locus with a herbicidally effective amount of a compound of formula (A) according to claim
 1. 